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OCR: Seymour Reichlin MD, PhD Professor of Medicine, Tufts University School of Medicine Division of Endocrinology, Diabetes, Metabolism and Molecular Medicine New England Medical Centre Hospitals Boston, Massachusetts, USA Edward O Reiter MD Professor of Pediatrics Tufts University School of Medicine, and Senior Physician and Chief Endocrinology Division New England Medical Centre Hospital Boston, Massachusetts, USA Louis M Sherwood MD Baumritter Professor and Chairman Department of Medicine, and Professor of Biochemistry, Albert Einstein College of Medicine New York, USA